Basal cell carcinoma is formed from the excessive growth of basal cells, which are cells that create new skin cells and create the outermost layer of epidermis. The excessive growth is caused by DNA damage. This damage modifies basal cell growth cycles and causes them to grow out of control into a mass of cancerous cells.
In a study
done about disease caused by ultraviolet radiation, it was revealed that 50-90% of basal cell carcinoma in fair skinned people is caused by radiation UV radiation. This UV radiation causes DNA damage, thus many causes of basal cell carcinoma can be attributed to exposure to UV radiation that causes the DNA damage. Here are various sources of UV radiation that could cause basal cell carcinoma:
DNA can still be damaged naturally, aside from UV radiation. As cells divide and new DNA is made for the new cells, a cell’s internal mechanisms might make a mistake in the creation of DNA and cause DNA damage that way. And although not a direct cause, a family history of basal cell carcinoma could also result in an inherited predisposition to basal cell carcinoma. This makes basal cells more prone to excessive growth.